β-Lactam Monotherapy vs β-Lactam–Macrolide Combination Treatment in Moderately Severe Community-Acquired Pneumonia
نویسندگان
چکیده
منابع مشابه
The controversy of combination vs monotherapy in the treatment of hospitalized community-acquired pneumonia.
BACKGROUND The majority of community-acquired pneumonia (CAP) patients (about 80%) will be treated as outpatients, because therapy with a single agent will work. For the remaining 20% of patients requiring hospitalization, there is some growing debate regarding the efficacy of different management approaches. For hospitalized patients, monotherapy with a respiratory fluoroquinolone agent seems ...
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No comparative effectiveness study has been conducted for the following 3 antibiotics: respiratory uoroquinolone, b-lactam, and blactam þ advanced macrolide. To gain insights into the real-world clinical effectiveness of these antibiotics for community-acquired pneumonia in adult outpatients, our study investigated the treatment failure rates in 2 million representative participants from the Na...
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Adding either macrolide or fluoroquinolone (FQ) to β-lactam has been recommended for patients with severe community-acquired pneumonia (CAP). However, due to the limited evidence available, there is a question as to the superiority of the two combination therapies. The MEDLINE, EMBASE, Cochrane Central Register, Scopus, and Web of Science databases were searched for systematic review and meta-a...
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82. The Association of Molecular Characteristics, Vancomycin MIC and Clinical Outcomes in Methicillin-susceptible Staphylococcus aureus Osteoarticular Infections in Children Jonathon McNeil, MD; Jesus G. Vallejo, MD, FIDSA; Louie Rosas, BS; Edward O. Mason Jr., PhD, FIDSA; Sheldon L. Kaplan, MD, FIDSA; Kristina G. Hulten, PhD; Pediatrics, Baylor College of Medicine, Houston, Texas; Pediatrics, ...
متن کاملMoxifloxacin monotherapy versus combination therapy in patients with severe community-acquired pneumonia evoked ARDS
BACKGROUND We tested the hypothesis that moxifloxacin monotherapy is equally effective and safe as a betalactam antibiotic based combination therapy in patients with acute respiratory distress syndrome (ARDS) evoked by severe community acquired pneumonia (CAP). METHODS In a retrospective chart review study of 229 patients with adult respiratory distress syndrome (ARDS) admitted to our intensi...
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ژورنال
عنوان ژورنال: JAMA Internal Medicine
سال: 2014
ISSN: 2168-6106
DOI: 10.1001/jamainternmed.2014.4887